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Liver Cancer Screening

Liver cancer is cancer that forms within the cells of the liver.
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Table of Contents

What is Liver Cancer?

Liver cancer is cancer that forms within the cells of the liver. The poor statistics behind liver cancer can be attributed to the various responsibilities of the liver. These include producing essential proteins, enzymes, and nutrients. The liver also plays an important role in the body’s digestion and metabolism and facilitates clearing toxins out of the body. When cancer occurs in the liver, all these important mechanisms in the body are disrupted subsequently jeopardising one’s likelihood of survival.

Another reason why liver cancer is so deadly could also be attributed to the high likelihood of patients with liver cancers also concurrently dealing with Hepatitis B1 in 25 people in Singapore is likely to have Hepatitis B and a recent study too, indicated that over 50% of liver cancer patients had a preceding condition of Hepatitis B. 

There are two types of liver cancer: 

  • Primary liver cancer or hepatocellular carcinoma: cancer cells originate from the liver organ. This is a common cancer that is seen in middle-aged men in Singapore.
  • Secondary liver cancer or metastatic liver cancer: cancer cells originate from other parts of the body but eventually spread to the liver.

Liver cancer is one of the top 10 most common cancer in Singapore with one of the poorest survival rates compared to other cancers. It is imperative to conduct routine screening and address any risk factors at the early stages. 

What Causes Liver Cancer?

As with every other cancer, the exact trigger of liver cancer is ambiguous. However, the most common assumption is that liver cancer occurs due to damage and scarring (fibrosis) known as cirrhosis. Excessive scarring reduces the function of the lover subsequently encouraging the growth of cancer cells. It is also possible for cancer cells to be activated through the mutation of the DNA of the liver cells. In other words, liver cancer can also occur without cirrhosis. 

What are the Symptoms of Liver Cancer?

Patients with liver cancer can present without any symptoms even when the cancer cells have progressed in size. However, as the cancer progresses, one can develop symptoms such as:

Unintentional weight loss
General tiredness
Loss of appetite
Bloatedness
Nausea or vomiting
Jaundice (yellowing of skin and eyes)
Palpable lump over abdomen/liver region
Tea-coloured/dark urine
Abdominal distension (swollen appearance or enlargement of the abdomen)
Visible veins on the abdomen
Unintentional weight loss
Jaundice (yellowing of skin and eyes)
Palpable lump over abdomen/liver region
Tea-coloured/dark urine
Abdominal distension (swollen appearance or enlargement of the abdomen)
Visible veins on the abdomen
General tiredness
Loss of appetite
Bloatedness
Nausea or vomiting

Is Liver Cancer Painful?

Liver cancer pain manifests as pain at the right side of the abdomen (where the liver is situated), pain at the right shoulder and back pain. Liver cancer pain has been described as “constant”, “dull”, and “sharp”, all of which are persistent.

Pain on the right shoulder is often a pain many find unsuspecting and surprising. This is known as referred pain where the pressure of the nerve at the liver causes pain in another part of the body. It is important to note that, it is common for pain to only occur in later stages. Do not wait till pain manifests before becoming proactive. Cancer screening will aid in early detection and treatment, thus improving survival rates.

Sexual Health Screening

STD screening tests generally involve blood tests, swab tests and urine tests.

Dr Ben Medical offers STD screening for commonly sexually transmitting conditions such as Chlamydia, Gonorrhea, warts, herpes, HIV, Syphilis and other more – highlighted comprehensively in our packages.

We also offer long term sexual health care and services:

  • Sexual health advice for patient and partners
  • Cervical cancer screening with pap smear, HPV testing
  • Cervical cancer vaccination

Who is at Risk of Liver Cancer in Singapore?

Whilst liver cancer can occur to anyone, there are some factors that increase your risk, these include: 

  • Family: if a parent, sibling, or child has been diagnosed with liver cancer, the chances of you also developing the condition quadruples
  • Habits and lifestyle: those who excessively consume alcohol have a higher risk of liver inflammation, liver cirrhosis, and liver cancer. Additionally, smoking also increases one’s risk as chemicals in cigarettes trigger cancer cell growth. 
  • Underlying health conditions: health conditions such as obesity and high cholesterol makes one prone to fatty liver. Over time, if the fatty liver remains uncontrolled and progresses, one can develop hardening of the liver (cirrhosis), which results in eventual primary liver cancer.
  • Environmental exposure: exposure to toxins such as aflatoxin increases the risk of liver inflammation and eventually liver cancer. Aflatoxins are found in nuts or meat and dairy from animals that have consumed contaminated feed. Additionally, certain jobs such as farmers or factory workers may also be exposed by inhaling these toxins.
  • Genetic conditions: such as genetic metabolic disorders like haemochromatosis leads to excessive deposition of iron in the body/especially liver, predisposing a person to develop primary liver cancer.

How is Liver Cancer Diagnosed in Singapore?

It is important to conduct routine screening to pick up health abnormalities particularly if you come to the realisation that you have one or more risk factors. Additionally, if you notice the persistence of any symptoms, it is best to seek medical intervention to rule out the possibility of liver cancer. Below are some of the medical procedures that will be conducted for diagnosis:

  • Physical examination and medical review: your doctor may attempt to identify any palpable lumps and risk factors that may increase your likelihood of liver cancer. 
  • Blood tests: will aid in identifying abnormalities in tumour markers such as alpha-fetoprotein (AFP). Additionally, a liver function test can also be conducted to measure different enzymes, proteins, and other substances in the blood made by the liver.
  • Liver ultrasound: visualises the condition of your liver and identifies issues like fatty liver and liver cancer. 
  • Computed tomography (CT) or Magnetic resonance imaging (MRI) scan: if suspicion increases during evaluation, you will have to undergo a CT or MRI scan to better analyse the conditions of your liver.
  • Liver biopsy: if abnormalities are identified, a tissue sample from your liver will be extracted to be examined in a laboratory.

Sexual Health Screening

STD screening tests generally involve blood tests, swab tests and urine tests.

Dr Ben Medical offers STD screening for commonly sexually transmitting conditions such as Chlamydia, Gonorrhea, warts, herpes, HIV, Syphilis and other more – highlighted comprehensively in our packages.

We also offer long term sexual health care and services:

  • Sexual health advice for patient and partners
  • Cervical cancer screening with pap smear, HPV testing
  • Cervical cancer vaccination

What are the Treatment Options for Liver Cancer in Singapore?

If suspected of liver cancer during examination and screening, you will be referred to a specialist, particularly a hepatologist or an oncologist. Once the diagnosis is confirmed, your specialist will discuss with you in detail to come up with an individualised treatment plan depending on the stage or extent of cancer, overall liver function, and any underlying medical condition. 

There are a range of treatments which may be explored such as surgery to resect the cancer region. A liver transplant may also be explored for patients with multiple cancer nodules, or those with advanced liver disease, or recurring cancer. Additionally, you may undergo chemotherapy, radiotherapy, or ablation therapy to destroy the cancer cells. Systemic treatment which involves oral medication would be explored if intensive medication is deemed inappropriate. 

A group of multidisciplined specialists will be involved in palliative treatment to manage the consequences and complications of cancer progression. The main objective of palliative care is to improve a patient’s quality of life.

Frequently Asked Questions

Although there are no absolute ways to prevent any form of cancer, you can lower your chances of developing liver cancer by considering an immunisation vaccine against Hepatitis B. 

Hepatitis B immunisation is currently part of the childhood national immunisation schedule in Singapore

However, as we age, some of us may have lost our immunity over time. It would be useful to run a blood test with your doctor to check your immunity status and consider a vaccination booster shot if required. Those with known family members with hepatitis B are advised to check their hepatitis B status.

It may be worth noting that vaccination for hepatitis cannot be administered after liver cancer diagnosis. Vaccinating as a preventative measure is arguably one of the best measures you can take. 

Patients with known hepatitis B or C infection should be followed up with their doctor for regular monitoring of the liver system. In patients with chronic inflammation from hepatitis B or C infection, your doctor may advise antiviral medication to control the progression of the disease and reduce the risk of developing liver cancer.

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